Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | TPMT | P51580 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17512364 | 0.87 | MAPK1 (0.60) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL1277038 | 0.81 | CA12 (0.61) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL2217173 | 0.81 | LTB4R (0.66) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL10742633 | 0.80 | CA12 (0.64) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL30362093 | 0.79 | LTB4R (0.64) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL15754270 | 0.79 | LTB4R (0.64) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL20053685 | 0.79 | LTB4R (0.64) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL7531177 | 0.79 | LTB4R (0.68) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL2217939 | 0.78 | CA12 (0.65) | MAPK1GAALTB4RPOLBMEN1 | |
| SCHEMBL6113978 | 0.78 | MEN1 (0.62) | MAPK1GAALTB4RPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630496-B1 | Antiinflammatory agents inhibit phospholipase 2, affecting both protaglandin and leukotriene production; indoles substituted in 2 position by 2,4-dioxo-thiazol-3-yl methylidene | GENETICS INSTITUTE LLC | 2003-10-07 | — | — | US | disclosed |
| EP-1062216-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999043672-A9 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INST (US) | 2000-05-04 | — | — | WO | disclosed |
| WO-1999043672-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | disclosed |