SCHEMBL7238744

SCHEMBL7238744

CCCc1ccc(Oc2ccc(/C(F)=C(\C)F)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.45
ACACB O00763 1/20 0.45
ACACA Q13085 1/20 0.45
PLK1 P53350 1/20 0.41
ALDH1A1 P00352 3/20 0.41
RAB9A P51151 2/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
SRD5A2 P31213 1/20 0.39
LPL P06858 1/20 0.38
LIPG Q9Y5X9 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
S1PR1 P21453 1/20 0.38
S1PR3 Q99500 1/20 0.38
POLB P06746 2/20 0.37
CTDSP1 Q9GZU7 2/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7238740 1.00 THRB (0.45) THRBACACBACACAPLK1ALDH1A1
SCHEMBL7238748 1.00 THRB (0.45) THRBACACBACACAPLK1ALDH1A1
SCHEMBL7230853 0.88 THRB (0.50) THRBPLK1ALDH1A1RAB9AMAPT
SCHEMBL7230865 0.88 THRB (0.50) THRBPLK1ALDH1A1RAB9AMAPT
SCHEMBL7230860 0.88 THRB (0.50) THRBPLK1ALDH1A1RAB9AMAPT
SCHEMBL7233329 0.84 THRB (0.47) THRBACACBACACAPLK1ALDH1A1
SCHEMBL7233325 0.84 THRB (0.47) THRBACACBACACAPLK1ALDH1A1
SCHEMBL7233321 0.84 THRB (0.47) THRBACACBACACAPLK1ALDH1A1
SCHEMBL7231000 0.84 L3MBTL1 (0.41) THRBACACBACACAPLK1ALDH1A1
SCHEMBL7231007 0.84 L3MBTL1 (0.41) THRBACACBACACAPLK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6623810-B2 Refractive index anisotropy SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-09-23 US disclosed
US-20010050353-A1 Phenylacetylene compound, liquid crystal composition, and liquid crystal element produced with the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-12-13 US disclosed
EP-0781827-B1 Liquid crystal mixture and liquid crystal device comprising the same SUMITOMO CHEMICAL CO (JP) 2001-06-13 EP disclosed
US-6149837-A SUBSTITUTED 1,4-BIS(SUBSTITUED PHENYLACETYLENE)BENZENE WHERE AT LEAST ONE RING HAS AN ALKYL ATTACHMENT, HAS A LARGE ANISOTROPY OF REFRACTIVE INDEX, TENDS TO BE MIXED WITH OTHER LIQUID CRYSTALS, IS LIGHT STABLE; LIQUID CRYSTAL ELEMENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-11-21 US disclosed
US-5866035-A LARGE BIREFRINGENCE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-02-02 US disclosed
EP-0781827-A1 Liquid crystal mixture and liquid crystal device comprising the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-07-02 EP disclosed