Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649195 | 0.83 | HDAC8 (0.60) | HDAC8EPHX2MAPK1RIPK1 | |
| SCHEMBL464347 | 0.82 | EPHX2 (0.70) | HDAC8EPHX2MAPK1 | |
| SCHEMBL7246422 | 0.80 | HDAC8 (0.46) | HDAC8EPHX2MAPK1RIPK1 | |
| SCHEMBL429344 | 0.79 | EPHX2 (0.66) | HDAC8EPHX2MAPK1 | |
| SCHEMBL1590871 | 0.79 | CA1 (0.44) | HDAC8 | |
| SCHEMBL7239677 | 0.77 | HDAC8 (0.46) | HDAC8EPHX2HDAC1HDAC6 | |
| SCHEMBL25330218 | 0.77 | EPHX2 (0.46) | HDAC8EPHX2MAPK1HDAC1HDAC6 | |
| SCHEMBL15540370 | 0.76 | RIPK1 (0.48) | RIPK1 | |
| SCHEMBL25329800 | 0.76 | RIPK1 (0.48) | RIPK1 | |
| SCHEMBL650261 | 0.75 | HDAC8 (0.56) | HDAC8MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602883-B1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-05 | — | — | US | disclosed |
| US-6387926-B1 | ANTICANCER AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2002-05-14 | — | — | US | disclosed |
| EP-0994856-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2000-12-06 | — | — | EP | disclosed |
| EP-0994856-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001434-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-14 | — | — | WO | disclosed |