Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | PNMT | P11086 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650261 | 0.83 | HDAC8 (0.56) | HDAC8 | |
| SCHEMBL8160279 | 0.80 | GRIA2 (0.44) | ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL7239168 | 0.77 | HDAC8 (0.52) | HDAC8EPHX2HDAC1HDAC6 | |
| SCHEMBL464347 | 0.74 | EPHX2 (0.70) | HDAC8EPHX2 | |
| SCHEMBL7420139 | 0.73 | PNMT (0.45) | BRD4ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL7420138 | 0.73 | PNMT (0.45) | BRD4ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL5862840 | 0.73 | MALT1 (0.47) | — | |
| SCHEMBL22397460 | 0.70 | PNMT (0.38) | HDAC8BRD4ADRA2APNMTADRA2B | |
| SCHEMBL7245975 | 0.70 | KDM1A (0.40) | BRD4ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL17785800 | 0.70 | PNMT (0.46) | BRD4ADRA2APNMTADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602883-B1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-05 | — | — | US | disclosed |
| US-6387926-B1 | ANTICANCER AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2002-05-14 | — | — | US | disclosed |
| EP-0994856-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2000-12-06 | — | — | EP | disclosed |
| EP-0994856-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001434-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-14 | — | — | WO | disclosed |