Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7242414 | 0.98 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7242405 | 0.86 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7232156 | 0.81 | LMNA (0.44) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7231459 | 0.79 | KDM4E (0.47) | SMN1; SMN2NPC1RAB9AHSD17B10KDM4E | |
| SCHEMBL4692335 | 0.77 | HSD17B10 (0.41) | SMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL4692150 | 0.77 | GRM1 (0.43) | SMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL18548584 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHSD17B10KDM4E | |
| SCHEMBL29660149 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHSD17B10KDM4E | |
| SCHEMBL3635932 | 0.75 | MAPT (0.46) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28686949 | 0.75 | EGFR (0.47) | SMN1; SMN2NPC1RAB9AHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250429-B2 | Aminomethyl-substituted thiazolobenzimidazole compounds | ASTELLAS PHARMA INC. (JP) | 2007-07-31 | — | — | US | disclosed |
| US-7250429-B2 | Aminomethyl-substituted thiazolobenzimidazole compounds | ASTELLAS PHARMA INC. (JP) | 2007-07-31 | — | — | US | disclosed |
| US-6642264-B1 | Thiazolo(3,2-a)benzoimidazole derivatives act specifically on metabotropic glutamate receptors and are used as medicaments. | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2003-11-04 | — | — | US | disclosed |
| EP-1167369-A1 | NOVEL THIAZOLOBENZIMIDAZOLE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-01-02 | — | — | EP | disclosed |