Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7239965 | 1.00 | CRHR1 (0.43) | CRHR1ABL1PIK3CA | |
| SCHEMBL6634750 | 1.00 | CRHR1 (0.43) | CRHR1ABL1PIK3CA | |
| SCHEMBL7243021 | 0.93 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7243025 | 0.93 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7243029 | 0.93 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7244915 | 0.90 | CRHR1 (0.41) | CRHR1ABL1PIK3CA | |
| SCHEMBL7245181 | 0.90 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7244912 | 0.90 | CRHR1 (0.41) | CRHR1ABL1PIK3CA | |
| SCHEMBL7244919 | 0.90 | CRHR1 (0.41) | CRHR1ABL1PIK3CA | |
| SCHEMBL5787588 | 0.87 | CRHR1 (0.42) | CRHR1ABL1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030195222-A1 | Substituted pyrimidinones and pyrimidinthiones | PHARMACIA & UPJOHN COMPANY | 2003-10-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195222-A1 | Substituted pyrimidinones and pyrimidinthiones | CRHR1, CRH, CRHR2 | CRHR1 1/4885ABL1 1018/4885PIK3CA 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.