Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18347395 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL18347410 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL4021576 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL18347399 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL3718479 | 0.73 | KDM4E (0.64) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL18347407 | 0.72 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL6311126 | 0.71 | POLB (0.54) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL7240869 | 0.71 | MEN1 (0.42) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL4716099 | 0.70 | FPR2 (0.55) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL27935752 | 0.70 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586462-B2 | ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists | ALLERGAN, INC. | 2003-07-01 | — | — | US | disclosed |
| US-20020187961-A1 | Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists | ALLERGAN, INC. | 2002-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020187961-A1 | Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists | PTGER2, PTGER1, PTGER3 | SMN1; SMN2 4248/4885POLB 2357/4885KMT2A 2076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.