Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.53 |
| ▸ | POLA1 | P09884 | 1/20 | 0.53 |
| ▸ | POLD1 | P28340 | 1/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18119004 | 0.93 | TK1 (0.59) | TK1POLBRNASE1POLA1POLD1 | |
| SCHEMBL288740 | 0.92 | TK1 (0.74) | TK1POLBPOLA1POLD1 | |
| SCHEMBL21068055 | 0.92 | TK1 (0.74) | TK1POLBPOLA1POLD1 | |
| SCHEMBL7038209 | 0.92 | TK1 (0.74) | TK1POLBPOLA1POLD1 | |
| SCHEMBL2384264 | 0.90 | POLB (0.62) | TK1POLBRNASE1POLA1POLD1 | |
| SCHEMBL14713599 | 0.89 | TK1 (0.60) | TK1POLBRNASE1POLA1POLD1 | |
| SCHEMBL19884474 | 0.89 | TK1 (0.61) | TK1POLBRNASE1ALBPKM | |
| SCHEMBL22855496 | 0.89 | TK1 (0.61) | TK1POLBRNASE1ALBPKM | |
| SCHEMBL2230026 | 0.89 | TK1 (0.67) | TK1RNASE1ALBPKMLMNA | |
| SCHEMBL8428685 | 0.89 | TK1 (0.67) | TK1RNASE1ALBPKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531476-B1 | Block multiplication of virus within body and restore immune functions by virtue of inhibitory activity toward platelet activating factor | UNIVERSITE PARIS 7 - DENIS DIDEROT (FR) | 2003-03-11 | — | — | US | disclosed |
| EP-1095029-B1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIV PARIS 7 DENIS DIDEROT (FR) | 2002-09-18 | — | — | EP | disclosed |
| EP-1095029-A1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIVERSITE PARIS 7 - Denis DIDEROT (FR) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001677-A1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIVERSITE PARIS 7 - DENIS DIDEROT (FR) | 2000-01-13 | — | — | WO | disclosed |