Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 8/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | ITK | Q08881 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7244700 | 0.91 | F2 (0.48) | F2CNR2CNR1NSD2HDAC1 | |
| SCHEMBL7247840 | 0.90 | NSD2 (0.52) | F2CNR2CNR1NSD2HDAC1 | |
| SCHEMBL7249869 | 0.86 | F2 (0.49) | F2CNR2CNR1NSD2HDAC1 | |
| SCHEMBL7245089 | 0.86 | F2 (0.52) | F2CNR2CNR1HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL7250157 | 0.85 | F2 (0.65) | F2CNR2 | |
| SCHEMBL6486632 | 0.84 | F2 (0.50) | F2HDAC1HDAC8HDAC6ITK | |
| SCHEMBL7246372 | 0.83 | PDK1 (0.51) | F2NSD2HDAC1HDAC8HDAC6 | |
| SCHEMBL7244672 | 0.83 | F2 (0.47) | F2HDAC1HDAC8HDAC6ITK | |
| Hydrochloric Acid SCHEMBL7244675 | 0.83 | F2 (0.49) | F2HDAC1HDAC8HDAC6ITK | |
| SCHEMBL7246953 | 0.81 | F2 (0.46) | F2CNR2CNR1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |