Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 6/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7247840 | 0.90 | NSD2 (0.52) | PDK1F2NSD2ITKRAB9A | |
| SCHEMBL7249769 | 0.88 | HSD17B10 (0.47) | PDK1F2ITKMAPTLMNA | |
| SCHEMBL7247078 | 0.87 | F2 (0.51) | PDK1F2ITKHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL7245594 | 0.86 | F2 (0.61) | F2RAB9ANAMPT | |
| SCHEMBL7249869 | 0.86 | F2 (0.49) | PDK1F2NSD2ITKHDAC1 | |
| SCHEMBL7244016 | 0.83 | F2 (0.49) | F2NSD2ITKHDAC1HDAC8 | |
| SCHEMBL7244700 | 0.82 | F2 (0.48) | F2NSD2ITKHDAC1HDAC8 | |
| SCHEMBL7245070 | 0.79 | F2 (0.53) | F2HDAC1HDAC8HDAC6 | |
| SCHEMBL8028362 | 0.79 | ITK (0.50) | PDK1F2ITKHDAC1HDAC6 | |
| SCHEMBL6486632 | 0.79 | F2 (0.50) | F2ITKRAB9AMAPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |