Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.69 |
| ▸ | PPARA | Q07869 | 15/20 | 0.69 |
| ▸ | PPARD | Q03181 | 8/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246044 | 0.91 | PPARG (0.74) | PPARGPPARAPPARD | |
| SCHEMBL5347950 | 0.91 | PPARG (0.70) | PPARGPPARAPPARDP2RX4 | |
| SCHEMBL6002510 | 0.90 | PPARG (0.77) | PPARGPPARA | |
| SCHEMBL6002523 | 0.88 | PPARG (0.81) | PPARGPPARAPPARD | |
| SCHEMBL7517998 | 0.86 | PPARG (0.66) | PPARGPPARAPPARDP2RX4 | |
| SCHEMBL7928584 | 0.85 | PPARG (0.81) | PPARGPPARAPPARD | |
| SCHEMBL5113340 | 0.83 | PPARG (0.49) | PPARGPPARAPPARD | |
| SCHEMBL7514537 | 0.82 | PPARG (0.74) | PPARGPPARAPPARD | |
| Ragaglitazar SCHEMBL676872 | 0.82 | PPARA (1.00) | PPARGPPARAPPARD | |
| Ragaglitazar SCHEMBL682732 | 0.82 | PPARA (1.00) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002537390-A | — | — | 2002-11-05 | — | — | JP | claimed |
| EP-1155006-A1 | NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | Dr. Reddy's Research Foundation (IN) | 2001-11-21 | — | — | EP | claimed |
| WO-2000050414-A1 | NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | DR.REDDY'S RESEARCH FOUNDATION (IN) | 2000-08-31 | — | — | WO | claimed |
| US-6608194-B1 | Hypolipidemic, antihyperglycemic, antiobesity and hypocholes-terolemic agents | DR. REDDY'S LABORATORIES LIMITED (IN) | 2003-08-19 | — | — | US | disclosed |
| US-6548666-B1 | Phenazine, phenoxazine, or phenothiazine derivatives; antilipemic, hypoglycemic, anticholesterol and antiobesity agents | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2003-04-15 | — | — | US | disclosed |
| US-6440961-B1 | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2002-08-27 | — | — | US | disclosed |
| EP-1155006-A1 | NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | Dr. Reddy's Research Foundation (IN) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050414-A1 | NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | DR.REDDY'S RESEARCH FOUNDATION (IN) | 2000-08-31 | — | — | WO | disclosed |