SCHEMBL7246729

SCHEMBL7246729

Cn1nc(-c2cccc(Cl)n2)cc1C(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
ALDH1A1 P00352 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
NPC1 O15118 1/20 0.41
GAA P10253 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
IDH1 O75874 6/20 0.39
IDH2 P48735 5/20 0.39
PTGES2 Q9H7Z7 1/20 0.38
RAB9A P51151 1/20 0.38
TP53 P04637 2/20 0.37
PDE10A Q9Y233 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12074976 0.79 L3MBTL1 (0.52) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL15048612 0.78 JAK2 (0.40) MAPTMEN1KMT2ASMN1; SMN2NPC1
SCHEMBL7246990 0.75 GAA (0.42) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL12075264 0.75 L3MBTL1 (0.53) ALDH1A1SMN1; SMN2NPC1GAAL3MBTL1
SCHEMBL7252955 0.75 RAB9A (0.44) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL25320046 0.73 MAPT (0.46) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL7256400 0.72 ADORA2A (0.44) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL13098073 0.72 TP53 (0.59) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL8108308 0.72 MAPT (0.44) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL15048611 0.71 PDE10A (0.40) MEN1KMT2AALDH1A1PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6528456-B2 Selectivity, desirable rate of degradation in soil BASF AKTIENGESELLSCHAFT (DE) 2003-03-04 US disclosed
US-20020137633-A1 Herbicidal 2-pyrazolyl-6-aryloxypyri(mi)dines BASF AKTIENEGESELLSCHAFT (DE) 2002-09-26 US disclosed
EP-1108720-A9 Herbicidal 2-Pyrazolyl-6-Aryloxy-Pyri(mi)dines BASF AKTIENGESELLSCHAFT (DE) 2001-10-31 EP disclosed
EP-1108720-A1 Herbicidal 2-Pyrazolyl-6-Aryloxy-Pyri(mi)dines BASF AKTIENGESELLSCHAFT (DE) 2001-06-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020137633-A1 Herbicidal 2-pyrazolyl-6-aryloxypyri(mi)dines DDT, CYP4X1, PRDX6 MAPT 4494/4885MEN1 4105/4885KMT2A 966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.