Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7241242 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDP2RX7GAACETP | |
| Hydrochloric Acid SCHEMBL7239359 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2HPGDP2RX7GAACETP | |
| Hydrochloric Acid SCHEMBL7238543 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2HPGDP2RX7GAACETP | |
| Hydrochloric Acid SCHEMBL7039656 | 0.72 | TSHR (0.35) | SMN1; SMN2HPGDP2RX7GAACETP | |
| Hydrochloric Acid SCHEMBL7037371 | 0.72 | TSHR (0.35) | SMN1; SMN2HPGDP2RX7GAACETP | |
| Hydrochloric Acid SCHEMBL7242340 | 0.70 | P2RX7 (0.38) | SMN1; SMN2HPGDP2RX7GAACETP | |
| Hydrochloric Acid SCHEMBL7041468 | 0.70 | SMN1; SMN2 (0.33) | SMN1; SMN2HPGDP2RX7GAACETP | |
| Hydrochloric Acid SCHEMBL7040765 | 0.70 | SMN1; SMN2 (0.33) | SMN1; SMN2HPGDP2RX7GAACETP | |
| Hydrochloric Acid SCHEMBL7041974 | 0.66 | GAA (0.35) | SMN1; SMN2HPGDP2RX7GAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7039902 | 0.66 | GAA (0.35) | SMN1; SMN2HPGDP2RX7GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630545-B2 | Polymerization catalyst of a metal complex with anionic, polycyclic, fused ring ligand system containing at least 4 fused rings, a cocatalyst and a butadiene or pentadiene | THE DOW CHEMICAL COMPANY | 2003-10-07 | — | — | US | disclosed |
| US-20020037981-A1 | Polymerization catalyst of a metal complex with anionic, polycyclic, fused ring ligand system containing at least 4 fused rings, a cocatalyst and a butadiene or pentadiene | DOW CHEMICAL COMPANY | 2002-03-28 | — | — | US | disclosed |