Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.74 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.54 |
| ▸ | CCR9 | P51686 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536869 | 0.88 | CCR2 (0.76) | CCR2GPR35CCR9 | |
| SCHEMBL7245116 | 0.87 | CCR2 (0.79) | CCR2SERPINE1GPR35 | |
| SCHEMBL3956751 | 0.86 | CCR2 (0.84) | CCR2CCR9 | |
| SCHEMBL3967526 | 0.85 | CCR2 (1.00) | CCR2CCR9 | |
| SCHEMBL3956671 | 0.83 | CCR2 (0.77) | CCR2GPR35CCR9PPARG | |
| SCHEMBL3963206 | 0.83 | CCR2 (0.79) | CCR2GPR35CCR9 | |
| SCHEMBL27543171 | 0.82 | CCR2 (0.58) | CCR2SERPINE1GPR35 | |
| SCHEMBL6303376 | 0.82 | CCR2 (0.78) | CCR2CCR9 | |
| SCHEMBL3967516 | 0.81 | CCR2 (0.73) | CCR2PPARG | |
| SCHEMBL30223430 | 0.80 | ABCB1 (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062216-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | claimed |
| WO-1999043672-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | claimed |
| US-6630496-B1 | Antiinflammatory agents inhibit phospholipase 2, affecting both protaglandin and leukotriene production; indoles substituted in 2 position by 2,4-dioxo-thiazol-3-yl methylidene | GENETICS INSTITUTE LLC | 2003-10-07 | — | — | US | disclosed |
| EP-1062216-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999043672-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | disclosed |