Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 9/20 | 0.76 |
| ▸ | CCR9 | P51686 | 1/20 | 0.62 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956751 | 0.92 | CCR2 (0.84) | CCR2CCR9KDM4EALDH1A1HPGD | |
| SCHEMBL4541643 | 0.90 | CCR2 (0.77) | CCR2CCR9GPR35KDM4EALDH1A1 | |
| SCHEMBL6867612 | 0.89 | CCR2 (0.61) | CCR2CCR9KDM4EALDH1A1HPGD | |
| SCHEMBL4371922 | 0.89 | CCR2 (0.75) | CCR2CCR9KDM4EALDH1A1HPGD | |
| SCHEMBL7247328 | 0.88 | CCR2 (0.74) | CCR2CCR9GPR35 | |
| SCHEMBL3967516 | 0.88 | CCR2 (0.73) | CCR2PLA2G4AABCB11SRD5A2 | |
| SCHEMBL3964251 | 0.87 | CCR2 (0.74) | CCR2CCR9GPR35ALDH1A1ABCB11 | |
| SCHEMBL29433700 | 0.87 | CCR2 (0.74) | CCR2CCR9GPR35ALDH1A1ABCB11 | |
| SCHEMBL6300956 | 0.87 | CCR2 (1.00) | CCR2ABCB11 | |
| SCHEMBL9622481 | 0.87 | NOD2 (0.64) | CCR2KDM4EALDH1A1HPGDPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |