Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | GLP1R | P43220 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255958 | 0.93 | GLP1R (0.43) | HTR2CF2HDAC1HDAC8GLP1R | |
| SCHEMBL7248938 | 0.90 | HTR2C (0.43) | HTR2CF2HDAC1HDAC8GLP1R | |
| SCHEMBL7250650 | 0.89 | GLP1R (0.48) | HTR2CF2HDAC1HDAC8GLP1R | |
| SCHEMBL6486632 | 0.87 | F2 (0.50) | F2HDAC1HDAC8GLP1RMAPT | |
| Hydrochloric Acid SCHEMBL7244675 | 0.86 | F2 (0.49) | F2HDAC1HDAC8GLP1RMAPT | |
| SCHEMBL7249842 | 0.81 | F2 (0.43) | HTR2CF2HDAC1HDAC8MAPT | |
| SCHEMBL7252575 | 0.80 | THRB (0.44) | HTR2CF2HDAC1HDAC8TSHR | |
| SCHEMBL7249812 | 0.79 | PPARG (0.42) | HTR2CF2HDAC1HDAC8HDAC6 | |
| SCHEMBL7249727 | 0.79 | F2 (0.41) | HTR2CF2HDAC1HDAC8MAPT | |
| SCHEMBL7250212 | 0.79 | F2 (0.45) | HTR2CF2HDAC1HDAC8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |