Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | GLP1R | P43220 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylpiperazine SCHEMBL7248311 | 0.90 | HTR2C (0.46) | HTR2CF2GLP1RHDAC1HDAC8 | |
| SCHEMBL7250212 | 0.89 | F2 (0.45) | HTR2CF2HDAC1HDAC8NTRK1 | |
| SCHEMBL7255958 | 0.86 | GLP1R (0.43) | HTR2CF2GLP1RHDAC1HDAC8 | |
| SCHEMBL7250650 | 0.86 | GLP1R (0.48) | HTR2CF2GLP1RHDAC1HDAC8 | |
| SCHEMBL6486632 | 0.84 | F2 (0.50) | F2GLP1RHDAC1HDAC8NTRK1 | |
| Hydrochloric Acid SCHEMBL7244675 | 0.83 | F2 (0.49) | F2GLP1RHDAC1HDAC8NTRK1 | |
| SCHEMBL7249609 | 0.82 | F2 (0.41) | F2GLP1RHDAC1HDAC8NTRK1 | |
| SCHEMBL7248203 | 0.78 | F2 (0.42) | HTR2CF2HDAC1HDAC8NTRK1 | |
| SCHEMBL7244672 | 0.76 | F2 (0.47) | F2HDAC1HDAC8NTRK1NTRK2 | |
| SCHEMBL7250244 | 0.76 | HTR2C (0.45) | HTR2CF2HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |