Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPFFR1 | Q9GZQ6 | 5/20 | 0.45 |
| ▸ | NPFFR2 | Q9Y5X5 | 5/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7254428 | 0.84 | CNR2 (0.52) | CYP2D6ALDH1A1NPFFR1NPFFR2OPRK1 | |
| SCHEMBL3334062 | 0.80 | SIGMAR1 (0.61) | CYP2D6MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL7251032 | 0.80 | NPFFR1 (0.56) | CYP2D6ALDH1A1NPFFR1NPFFR2OPRK1 | |
| SCHEMBL6887496 | 0.79 | CYP2D6 (0.48) | CYP2D6MEN1KMT2AALDH1A1NPFFR1 | |
| SCHEMBL7253609 | 0.79 | CYP3A4 (0.49) | CYP2D6MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL2277424 | 0.78 | CYP2D6 (0.51) | CYP2D6MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL20571382 | 0.78 | CYP3A4 (0.54) | CYP2D6MEN1KMT2AALDH1A1NPFFR1 | |
| SCHEMBL7249627 | 0.77 | MAPK1 (0.50) | CYP2D6MEN1KMT2AALDH1A1NPFFR1 | |
| SCHEMBL4630842 | 0.76 | POLB (0.57) | MEN1KMT2AALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL7248229 | 0.76 | NPFFR1 (0.60) | NPFFR1NPFFR2OPRK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545022-B1 | Treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, inflammatory diseases, and gastrointestinal disorders | PFIZER INC. | 2003-04-08 | — | — | US | disclosed |