Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 17/20 | 0.60 |
| ▸ | NPFFR2 | Q9Y5X5 | 17/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7251032 | 0.86 | NPFFR1 (0.56) | NPFFR1NPFFR2OPRK1OPRD1OPRM1 | |
| SCHEMBL7249859 | 0.86 | NPFFR1 (0.52) | NPFFR1NPFFR2OPRK1 | |
| SCHEMBL7249605 | 0.81 | POLB (0.45) | — | |
| SCHEMBL7249447 | 0.81 | ALDH1A1 (0.44) | NPFFR1NPFFR2 | |
| SCHEMBL7250646 | 0.81 | ALDH1A1 (0.44) | — | |
| SCHEMBL7248709 | 0.80 | NPFFR1 (0.51) | NPFFR1NPFFR2OPRK1 | |
| SCHEMBL7248648 | 0.80 | ALDH1A1 (0.44) | — | |
| SCHEMBL3334062 | 0.79 | SIGMAR1 (0.61) | SIGMAR1OPRM1 | |
| SCHEMBL7249154 | 0.79 | CA1 (0.44) | — | |
| SCHEMBL6079469 | 0.77 | POLB (0.59) | SIGMAR1OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045834-A1 | 4(3)SUBSTITUTED-4(3)-AMINOMETHYL-(THIO)PYRAN OR -PIPERIDINE DERIVATIVES (=GABAPENTIN ANALOGUES), THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999031057-A1 | 4(3)SUBSTITUTED-4(3)-AMINOMETHYL-(THIO)PYRAN OR -PIPERIDINE DERIVATIVES (=GABAPENTIN ANALOGUES), THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | WARNER-LAMBERT COMPANY (US) | 1999-06-24 | — | — | WO | claimed |
| US-6545022-B1 | Treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, inflammatory diseases, and gastrointestinal disorders | PFIZER INC. | 2003-04-08 | — | — | US | disclosed |