Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.52 |
| ▸ | MMP9 | P14780 | 7/20 | 0.52 |
| ▸ | MMP13 | P45452 | 6/20 | 0.52 |
| ▸ | MMP3 | P08254 | 3/20 | 0.52 |
| ▸ | MMP14 | P50281 | 3/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | MMP10 | P09238 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12152323 | 0.89 | MMP2 (0.61) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL7249415 | 0.89 | POLB (0.44) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL7248141 | 0.84 | MMP2 (0.49) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL7249713 | 0.83 | MAPT (0.46) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL6782627 | 0.80 | MMP2 (0.56) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4816291 | 0.79 | ADAMTS4 (0.60) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL7255900 | 0.79 | MMP2 (0.46) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL6785924 | 0.73 | MMP2 (0.52) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL6787148 | 0.73 | MMP2 (0.51) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL6950652 | 0.72 | MMP2 (0.58) | MMP2MMP9MMP13MMP3MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503910-B1 | Metalloproteinase inhibitors; antimetastasis agents; arthritis, neurodegenerative disorder treatment | DARWIN DISCOVERY LTD. (GB) | 2003-01-07 | — | — | US | claimed |
| EP-1177183-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2002-02-06 | — | — | EP | claimed |
| WO-2000069839-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-11-23 | — | — | WO | claimed |