Phenylbutanoic Acid

Phenylbutanoic Acid

SCHEMBL724890

NCc1ccccc1.O=C(O)CCCc1ccccc1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.81
HDAC3 O15379 3/20 0.81
HDAC2 Q92769 3/20 0.81
HDAC8 Q9BY41 3/20 0.81
HDAC6 Q9UBN7 3/20 0.81
HDAC5 Q9UQL6 3/20 0.81
HDAC4 P56524 2/20 0.81
HDAC7 Q8WUI4 2/20 0.81
HDAC10 Q969S8 2/20 0.81
HDAC11 Q96DB2 2/20 0.81
HDAC9 Q9UKV0 2/20 0.81
MAPK1 P28482 1/20 0.81
ADRA1A P35348 1/20 0.81
SLC6A3 Q01959 1/20 0.81
SMN1; SMN2 Q16637 1/20 0.81
MAPT P10636 1/20 0.69
RXFP1 Q9HBX9 1/20 0.69
KEAP1 Q14145 1/20 0.61
FFAR1 O14842 4/20 0.59
NPC1 O15118 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11007974 0.92 SMN1; SMN2 (0.67) HDAC1HDAC3HDAC2HDAC8HDAC6
Glutarate SCHEMBL28239405 0.90 HDAC3 (0.63) HDAC1HDAC3HDAC2HDAC8HDAC6
Adipic Acid SCHEMBL15656104 0.90 MAPT (0.64) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL1021513 0.90 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL21219015 0.90 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL1716 0.90 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL1666941 0.89 SMN1; SMN2 (0.63) HDAC1HDAC3HDAC2HDAC8HDAC6
Sebacic Acid SCHEMBL7203711 0.88 MAPT (0.68) HDAC1HDAC3HDAC2HDAC8HDAC6
Azelaic Acid SCHEMBL31309960 0.88 MAPT (0.68) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL726614 0.88 HDAC1 (0.95) HDAC1HDAC3HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011160821-A2 ORGANIC SALTS AND CO-CRYSTALS OF PHENYLBUTYRIC ACID LUNAMED AG (CH) 2011-12-29 WO disclosed
EP-2397458-A1 Organic salts and co-crystals of phenylbutyric acid Lunamed AG (CH) 2011-12-21 EP disclosed