Phenylbutanoic Acid

Phenylbutanoic Acid

SCHEMBL726614

O=C(O)CCCc1ccccc1.[NaH]

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.95
HDAC3 O15379 3/20 0.95
HDAC2 Q92769 3/20 0.95
HDAC8 Q9BY41 3/20 0.95
HDAC6 Q9UBN7 3/20 0.95
HDAC5 Q9UQL6 3/20 0.95
HDAC4 P56524 2/20 0.95
HDAC7 Q8WUI4 2/20 0.95
HDAC10 Q969S8 2/20 0.95
HDAC11 Q96DB2 2/20 0.95
HDAC9 Q9UKV0 2/20 0.95
MAPK1 P28482 1/20 0.95
ADRA1A P35348 1/20 0.95
SLC6A3 Q01959 1/20 0.95
SMN1; SMN2 Q16637 1/20 0.95
MAPT P10636 1/20 0.80
RXFP1 Q9HBX9 1/20 0.80
KEAP1 Q14145 1/20 0.71
FFAR1 O14842 6/20 0.67
NPC1 O15118 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenylbutanoic Acid SCHEMBL1716 0.98 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL21219015 0.98 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL1021513 0.98 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL28684695 0.95 HDAC1 (0.95) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL29272534 0.95 HDAC1 (0.95) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL2010634 0.95 HDAC1 (0.95) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL7723613 0.95 HDAC1 (0.95) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL31228551 0.95 HDAC1 (0.95) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL29272542 0.95 HDAC1 (0.95) HDAC1HDAC3HDAC2HDAC8HDAC6
Phenylbutanoic Acid SCHEMBL27900207 0.95 HDAC1 (0.95) HDAC1HDAC3HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107841532-A Screen the method for anti-breast cancer transfer compounds and the application of related compound 清华大学 2018-03-27 CN claimed
EP-3185903-A1 PRODUCTS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS COURSING WITH A COGNITION DEFICIT OR IMPAIRMENT, AND OF NEURODEGENERATIVE DISEASES Fundación para la Investigación Médica Aplicada (ES) 2017-07-05 EP claimed
WO-2016030345-A1 PRODUCTS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS COURSING WITH A COGNITION DEFICIT OR IMPAIRMENT, AND OF NEURODEGENERATIVE DISEASES FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) 2016-03-03 WO claimed
EP-1847274-A1 Association of phenylbutyrate, ATRA and cytidine and its use in anti-tumour therapy CIPROSA LLC - Corporate Creations Network, Inc. (US) 2007-10-24 EP claimed
US-20250377351-A1 METHOD FOR IDENTIFYING EFFECTIVE TREATMENTS AGAINST NEURODEGENERATIVE DISORDERS AcuraStem Incorporated (US) 2025-12-11 US disclosed
WO-2024211633-A1 POLYPEPTIDE ADJUVANTS AND USES THEREOF BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-10-10 WO disclosed
US-20240252594-A1 COMBINATION THERAPY FOR NEURODEGENERATIVE DISEASES ALETA NEUROSCIENCE LLC (US) 2024-08-01 US disclosed
US-20240058288-A1 DRUG COCKTAIL FOR TREATMENT OF PARKINSON'S DISEASE, LEWY BODY DISEASE AND MULTIPLE SYSTEM ATROPHY ALETA NEUROSCIENCE LLC (US) 2024-02-22 US disclosed
US-20240041807-A1 COMBINATION THERAPY TO TREAT UREA CYCLE DISORDERS BAYLOR COLLEGE OF MEDICINE 2024-02-08 US disclosed
US-11819483-B2 Combination therapy to treat urea cycle disorders BAYLOR COLLEGE OF MEDICINE (US) 2023-11-21 US disclosed
US-20230181504-A1 COMBINATION THERAPY TO TREAT UREA CYCLE DISORDERS BAYLOR COLLEGE OF MEDICINE 2023-06-15 US disclosed
WO-2023042178-A2 COMBINATION THERAPY FOR NEURODEGENERATIVE DISEASES ALETA NEUROSCIENCE, LLC (US) 2023-03-23 WO disclosed
EP-1334358-A1 TARGETING CELLS HAVING MAD2 MUTATION FOR TREATMENT AND/OR PREVENTION OF DISEASE Regents of the University of California (US) 2003-08-13 EP disclosed
WO-2003044525-A1 TARGETING CELLS HAVING MAD2 MUTATION FOR TREATMENT AND/OR PREVENTION OF DISEASE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2003-05-30 WO disclosed
WO-2003042411-A2 USE OF MUTATIONS OF MEC-1 AND ITS RELATED GENES IN THE IDENTIFICATION OF COMPOUNDS FOR TREATMENT OF DISEASE FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2003-05-22 WO disclosed
WO-2003022253-A1 DOSAGE FORMS HAVING PROLONGED ACTIVE INGREDIENT RELEASE LUNAMED AG (CH) 2003-03-20 WO disclosed
EP-1291015-A1 Dosage forms having prolonged active ingredient release Lunamed AG (CH) 2003-03-12 EP disclosed
CN-1369297-A Mixture of four ginseng for promoting blood circulation and preparation method thereof LIU FENGYI (CN) 2002-09-18 CN disclosed
US-20020054912-A1 Microparticles BOARD OF TRUSTEES OF UNIVERSITY OF LLINOIS 2002-05-09 US disclosed
WO-2002013786-A2 METHOD OF FORMING MICROPARTICLES BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2002-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240058288-A1 DRUG COCKTAIL FOR TREATMENT OF PARKINSON'S DISEASE, LEWY BODY DISEASE AND MULTIPLE SYSTEM ATROPHY BAG3, BAG2, PHB1 HDAC1 2195/4885HDAC3 1561/4885HDAC2 2457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.