Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7249605 | 0.82 | POLB (0.45) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL7249447 | 0.82 | ALDH1A1 (0.44) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL7250646 | 0.82 | ALDH1A1 (0.44) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL7248648 | 0.81 | ALDH1A1 (0.44) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL7249859 | 0.80 | NPFFR1 (0.52) | ALDH1A1LMNARAB9AL3MBTL1KMT2A | |
| SCHEMBL7248229 | 0.79 | NPFFR1 (0.60) | — | |
| SCHEMBL28743311 | 0.73 | ALDH1A1 (0.40) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL27573109 | 0.72 | POLB (0.42) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL2877082 | 0.71 | NPFFR1 (0.56) | ALDH1A1LMNAGAAKMT2AMEN1 | |
| SCHEMBL27448810 | 0.71 | HPGD (0.49) | CA1CA2CA5ACA7CA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545022-B1 | Treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, inflammatory diseases, and gastrointestinal disorders | PFIZER INC. | 2003-04-08 | — | — | US | disclosed |