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SCHEMBL7249509

SCHEMBL7249509

CCCCCCC(=O)NNC(=N)c1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1[S+](C)[O-]

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ GABRA2 P47869 20/20 0.40
▸ GABRB2 P47870 20/20 0.40
▸ GABRP O00591 19/20 0.40
▸ GABRD O14764 19/20 0.40
▸ GABRA1 P14867 19/20 0.40
▸ GABRB1 P18505 19/20 0.40
▸ GABRG2 P18507 19/20 0.40
▸ GABRB3 P28472 19/20 0.40
▸ GABRA5 P31644 19/20 0.40
▸ GABRA3 P34903 19/20 0.40
▸ GABRA4 P48169 19/20 0.40
▸ GABRE P78334 19/20 0.40
▸ GABRA6 Q16445 19/20 0.40
▸ GABRG1 Q8N1C3 19/20 0.40
▸ GABRG3 Q99928 19/20 0.40
▸ GABRQ Q9UN88 19/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7243268 1.00 GABRA2 (0.40) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7250584 1.00 GABRA2 (0.40) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7242869 0.99 GABRP (0.40) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7249353 0.97 GABRP (0.41) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7242935 0.90 GABRP (0.43) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7247018 0.89 GABRA2 (0.42) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7250501 0.89 GABRA2 (0.42) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7501240 0.88 GABRP (0.43) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7249007 0.88 GABRP (0.42) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7250236 0.85 GABRP (0.43) GABRA2GABRB2GABRPGABRDGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030144251-A1 Pesticidal 1-arylpyrazoles RHONE-POULENC INC. 2003-07-31 — — US claimed
EP-0948485-B1 PESTICIDAL 1-ARYLPYRAZOLES AVENTIS CROPSCIENCE SA (FR) 2002-09-25 — — EP claimed
US-20020045758-A1 Pesticidal 1-arylpyrazoles RHONE-POULENC INC. 2002-04-18 — — US claimed
US-20030144251-A1 Pesticidal 1-arylpyrazoles RHONE-POULENC INC. 2003-07-31 — — US disclosed
US-6500850-B2 1-ARYLPYRAZOLE OXIME DERIVATIVES; SAFE SYSTEMIC INSECTICIDES FOR CONTROL OF ARTHROPOD, NEMATODE, HELMINTH OR PROTOZOAN PESTS RHONE-POULENC INC. 2002-12-31 — — US disclosed
EP-0948485-B1 PESTICIDAL 1-ARYLPYRAZOLES AVENTIS CROPSCIENCE SA (FR) 2002-09-25 — — EP disclosed
US-20020045758-A1 Pesticidal 1-arylpyrazoles RHONE-POULENC INC. 2002-04-18 — — US disclosed
US-6350771-B1 Pesticidal 1-arylpyrazoles RHONE-POULENC, INC. 2002-02-26 — — US disclosed
WO-1999017613-A1 METHODE OF INSECT CONTROL RHONE-POULENC AGRO (FR) 1999-04-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020045758-A1 Pesticidal 1-arylpyrazoles CYP1B1, CYP2E1, CYP1A1 GABRA2 2380/4885GABRB2 1699/4885GABRP 1208/4885
US-20030144251-A1 Pesticidal 1-arylpyrazoles CYP1B1, CYP2E1, CYP1A1 GABRA2 2380/4885GABRB2 1699/4885GABRP 1208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.