Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.35 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24417654 | 0.76 | HTR2C (0.40) | HTR2CADORA3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7248887 | 0.73 | MAPK1 (0.30) | — | |
| SCHEMBL25587172 | 0.72 | ADORA3 (0.39) | HTR2CADORA3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6036214 | 0.66 | HTR2C (0.39) | HTR2CADORA3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20187293 | 0.64 | KMT2A (0.43) | HTR2CADORA3SMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL1704402 | 0.63 | GRN (0.48) | SMN1; SMN2NPC1RAB9ACYP19A1GRN | |
| SCHEMBL7595267 | 0.63 | CNR1 (0.47) | HTR2CNPC1RAB9AL3MBTL1CYP19A1 | |
| SCHEMBL3532926 | 0.63 | KMT2A (0.60) | ADORA3L3MBTL1CYP19A1LMNAALDH1A1 | |
| SCHEMBL11154472 | 0.63 | KMT2A (0.43) | ADORA3CYP19A1ALDH1A1KMT2A | |
| SCHEMBL20187309 | 0.63 | SMN1; SMN2 (0.58) | ADORA3SMN1; SMN2NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617347-B1 | Substituted pyrazoles are treatment of Type II diabetes and obesity. | ELI LILLY AND COMPANY | 2003-09-09 | — | — | US | disclosed |
| US-6232337-B1 | USEFUL IN THE TREATMENT OF TYPE II DIABETES AND OBESITY | ELI LILLY AND COMPANY | 2001-05-15 | — | — | US | disclosed |
| US-6046227-A | USEFUL IN THE TREATMENT OF TYPE II DIABETES AND OBESITY; A SUBSTITUTED PYRAZINE COMPOUND | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999029673-A1 | SELECTIVE β3 ADRENERGIC AGONISTS | ELI LILLY AND COMPANY (US) | 1999-06-17 | — | — | WO | disclosed |
| EP-0921120-A1 | Selective beta 3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 1999-06-09 | — | — | EP | disclosed |