Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7251803 | 0.83 | HRH3 (0.41) | HRH3MEN1KMT2ACYP2D6OPRK1 | |
| SCHEMBL6097389 | 0.82 | HRH3 (0.45) | HRH3CETPEPHX2ELOVL6MEN1 | |
| SCHEMBL7244146 | 0.81 | KDM1A (0.37) | HRH3EPHX2PGRCYP2D6KDM1A | |
| SCHEMBL7251663 | 0.80 | CYP2D6 (0.39) | MEN1CYP2D6KDM1AOPRK1 | |
| SCHEMBL7245322 | 0.80 | MGLL (0.41) | PGRTBXA2R | |
| SCHEMBL5965660 | 0.79 | HRH3 (0.39) | HRH3CETPEPHX2ELOVL6PGR | |
| SCHEMBL7251058 | 0.79 | GRIN2B (0.37) | CYP2D6KDM1AOPRK1 | |
| SCHEMBL7244084 | 0.79 | HRH3 (0.43) | HRH3MEN1KMT2ACYP2D6OPRK1 | |
| SCHEMBL7248955 | 0.77 | HRH3 (0.37) | HRH3MEN1CYP2D6OPRK1 | |
| SCHEMBL7248514 | 0.77 | DRD2 (0.44) | HRH3CYP2D6OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559162-B2 | Electrophysiological activity | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | disclosed |
| EP-1244631-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047893-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |