Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242668 | 0.92 | POLB (0.40) | SLC6A4HRH3GRIN2BPOLB | |
| SCHEMBL7244465 | 0.87 | HRH3 (0.37) | SLC6A4HRH3 | |
| SCHEMBL5965546 | 0.84 | MGLL (0.41) | MGLLMMP1MMP3MMP7MMP9 | |
| SCHEMBL7246406 | 0.83 | HRH3 (0.37) | SLC6A4HRH3 | |
| SCHEMBL7242638 | 0.83 | MGLL (0.39) | MGLLSLC6A4HRH3TBXA2RDRD3 | |
| SCHEMBL7242632 | 0.82 | SLC6A4 (0.40) | SLC6A4HRH3 | |
| SCHEMBL7242841 | 0.80 | SLC6A4 (0.39) | SLC6A4HRH3GRIN2B | |
| SCHEMBL7250046 | 0.80 | MCHR1 (0.43) | SLC6A4HRH3 | |
| SCHEMBL5965521 | 0.80 | MGLL (0.41) | MGLLSLC6A4HRH3TBXA2RDRD3 | |
| SCHEMBL7245376 | 0.79 | HRH3 (0.40) | SLC6A4HRH3DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559162-B2 | Electrophysiological activity | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | disclosed |
| EP-1244631-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047893-A1 | NEW AZABICYCLOOCTANE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |