Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7251505 | 1.00 | MAOA (0.55) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL6752771 | 0.93 | MAOA (0.51) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL1158153 | 0.87 | IDO1 (0.61) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL11426742 | 0.87 | IDO1 (0.61) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL1158152 | 0.87 | IDO1 (0.61) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL9434277 | 0.81 | MAOA (0.51) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL9434278 | 0.81 | MAOA (0.51) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL31453511 | 0.80 | MAOA (0.56) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL31453513 | 0.79 | TRPA1 (0.63) | MAOAMAOBIDO1KMT2AMEN1 | |
| SCHEMBL9522633 | 0.77 | PPARG (0.55) | MAOAMAOBIDO1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610731-B2 | Antiinflammatory | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-26 | — | — | US | disclosed |
| US-6403632-B1 | CYCLIC AMIDE DERIVATIVE | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-06-11 | — | — | US | disclosed |