Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 13/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 13/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ACVR1B | P36896 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.45 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.45 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722515 | 0.90 | ACVR1 (0.47) | ACVR1TGFBR1HTR7PDE4C | |
| SCHEMBL15210578 | 0.82 | NCF1 (0.55) | ACVR1TGFBR1BMPR1AACVRL1RIPK2 | |
| SCHEMBL10267650 | 0.81 | FYN (0.54) | ABL1PDE4C | |
| SCHEMBL30765219 | 0.80 | CFTR (0.47) | ACVR1TGFBR1BMPR1AACVRL1RIPK2 | |
| SCHEMBL16638609 | 0.80 | PDE4C (0.50) | PDE4C | |
| SCHEMBL722839 | 0.80 | PDE4C (0.51) | PDE4C | |
| SCHEMBL723093 | 0.79 | PDE4C (0.55) | PDE4C | |
| SCHEMBL723597 | 0.79 | FYN (0.54) | ACVR1TGFBR1BMPR1AACVRL1ABL1 | |
| SCHEMBL722343 | 0.79 | PDE4C (0.47) | RIPK2NLKPDE4C | |
| SCHEMBL722998 | 0.78 | PDE4C (0.41) | ACVR1TGFBR1PDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | claimed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |