Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.54 |
| ▸ | MEN1 | O00255 | 9/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | PLEC | Q15149 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11643203 | 0.77 | KDM4E (0.53) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL2435022 | 0.77 | MAPT (0.61) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL9040846 | 0.76 | MAPT (0.41) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL7252443 | 0.76 | ALKBH5 (0.54) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL11326873 | 0.74 | MEN1 (0.51) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL11638385 | 0.74 | CYP2C19 (0.38) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL7883066 | 0.70 | ALKBH5 (0.64) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL7234970 | 0.70 | MAPT (0.57) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL11532160 | 0.69 | MAPT (0.52) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL10373537 | 0.68 | MAPT (0.50) | MAPTMEN1KMT2AHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670387-B1 | Thrombocytopenia; hydroxy-1-azo-naphthalene derivatives; 3-hydroxy-4-((2-hydroxy-1-naphthalenyl)azo-)-1-naphthalenesul fonic acid; promoters of thrombopoiesis and megakaryocytopoi esis; enhancing platelet production; agonizing TPO receptor | SMITHKLINE BEECHAM CORPORATION | 2003-12-30 | — | — | US | disclosed |
| EP-1156804-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1156804-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000035446-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
| EP-0274642-B1 | HERBICIDAL AND FUNGICIDAL AGENTS BASED ON SUBSTITUTED PYRAZOLIN-5-ONE DERIVATIVES | BAYER AG (DE) | 1993-08-11 | — | — | EP | disclosed |
| US-5162528-A | Pre- and post-emergence; phytaphthora in tomato plants; rice and wheat | BAYER AKTIENGESELLSCHAFT (DE) | 1992-11-10 | — | — | US | disclosed |
| US-5028717-A | Herbicidal and fungicidal agents based on substituted pyrazolin-5-one derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1991-07-02 | — | — | US | disclosed |
| US-4909827-A | Containing a C6-10 aryl group substituted in position 1 | BAYER AKTIENGESELLSCHAFT (DE) | 1990-03-20 | — | — | US | disclosed |
| EP-0274642-A2 | Herbicidal and fungicidal agents based on substituted pyrazolin-5-one derivatives | BAYER AG (DE) | 1988-07-20 | — | — | EP | disclosed |