Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | GLA | P06280 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493170 | 0.89 | ESR1 (0.45) | ESR1ESR2KDM4ETDP1POLB | |
| SCHEMBL4501863 | 0.87 | CDK4 (0.44) | ESR1CDK4CCND1KDM4ETDP1 | |
| SCHEMBL4892024 | 0.80 | CDK4 (0.41) | ESR1CDK4CCND1KDM4ETDP1 | |
| SCHEMBL30557325 | 0.80 | CDK4 (0.41) | ESR1CDK4CCND1KDM4ETDP1 | |
| SCHEMBL9307675 | 0.77 | ESR1 (0.44) | ESR1ESR2KDM4ETDP1POLB | |
| SCHEMBL7532714 | 0.73 | ALDH1A1 (0.47) | ESR1ESR2KDM4ETDP1POLB | |
| SCHEMBL4501936 | 0.70 | CDK4 (0.43) | ESR1CDK4CCND1KDM4ETDP1 | |
| SCHEMBL420380 | 0.69 | CDK4 (0.54) | ESR1ESR2CDK4CCND1KDM4E | |
| SCHEMBL4495841 | 0.68 | MAPK10 (0.42) | ESR1KDM4ETDP1POLBL3MBTL1 | |
| SCHEMBL29588824 | 0.68 | MAPK10 (0.42) | ESR1KDM4ETDP1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534496-B1 | Prophylactic and/or therapeutic drug for obesity and obesity associated diseasestor diabetes with a reduced risk for central side effects and high universality in usage. Another object of the a lipolytic agent, or a prophylactic and/or | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2003-03-18 | — | — | US | disclosed |