Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 3/20 | 0.36 |
| ▸ | CASP7 | P55210 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30557325 | 1.00 | CDK4 (0.41) | CDK4CCND1ADORA2AALDH1A1KDM4E | |
| SCHEMBL4501863 | 0.92 | CDK4 (0.44) | CDK4CCND1ADORA2AALDH1A1KDM4E | |
| SCHEMBL7252826 | 0.80 | ESR1 (0.37) | CDK4CCND1ADORA2AALDH1A1KDM4E | |
| SCHEMBL1859838 | 0.78 | CDK4 (0.39) | CDK4CCND1ALDH1A1KDM4EHPGD | |
| SCHEMBL4501936 | 0.77 | CDK4 (0.43) | CDK4CCND1ADORA2AALDH1A1KDM4E | |
| SCHEMBL29588824 | 0.71 | MAPK10 (0.42) | ADORA2AALDH1A1KDM4EHPGDELANE | |
| SCHEMBL4495841 | 0.71 | MAPK10 (0.42) | ADORA2AALDH1A1KDM4EHPGDELANE | |
| SCHEMBL2049719 | 0.71 | KDM4E (0.46) | ALDH1A1KDM4EHPGDHSD17B10MAOA | |
| SCHEMBL10944923 | 0.70 | ALDH1A1 (0.61) | CDK4CCND1ALDH1A1KDM4EHPGD | |
| SCHEMBL220864 | 0.69 | CYP1A2 (0.44) | ALDH1A1KDM4EHPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341220-B | Photochromic compositions with polyols and poly (anhydrides) | 光学转变有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-114341220-B | Photochromic compositions with polyols and poly (anhydrides) | 光学转变有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-114341220-A | Photochromic compositions with polyols and poly (anhydrides) | 光学转变有限公司 | 2022-04-12 | — | — | CN | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| CN-113227259-A | Indol naphthopyrans and photochromic compositions comprising same | 光学转变有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-113227098-A | Indol naphthopyrans | 光学转变有限公司 | 2021-08-06 | — | — | CN | disclosed |
| US-7459555-B2 | Photochromic naphthopyrans | RODENSTOCK GMBH (DE) | 2008-12-02 | — | — | US | disclosed |
| US-20020052499-A1 | Photochromic naphthopyrans | OPTISCHE WERKE G. RODENSTOCK | 2002-05-02 | — | — | US | disclosed |
| EP-1005464-B1 | PHOTOCHROMIC NAPHTHOPYRANS | RODENSTOCK OPTIK G (DE) | 2002-04-17 | — | — | EP | disclosed |
| US-6342459-B1 | PHOTOCHROMIC COMPOUNDS AND ARTICLES OF RESIN FOR OPTHTHALMIC LENSES | OPTISCHE WERKE G. RODENSTOCK (DE) | 2002-01-29 | — | — | US | disclosed |
| EP-1005464-A1 | PHOTOCHROMIC NAPHTHOPYRANS | Optische Werke G. Rodenstock (DE) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999067234-A1 | PHOTOCHROMIC NAPHTHOPYRANS | OPTISCHE WERKE G. RODENSTOCK (DE) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052499-A1 | Photochromic naphthopyrans | BPNT1, NR2E3, BRIX1 | CDK4 2293/4885CCND1 595/4885ADORA2A 3378/4885 |
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | CDK4 689/4885CCND1 132/4885ADORA2A 240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.