Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9180743 | 0.86 | ACLY (0.52) | ACLYACACBACACACES2PPARA | |
| Gemcabene SCHEMBL761631 | 0.86 | ACLY (0.55) | ACLYACACBACACAPPARALTB4R | |
| SCHEMBL9182628 | 0.84 | ACLY (0.55) | ACLYACACBACACACES2PPARA | |
| SCHEMBL5524941 | 0.84 | ACLY (0.59) | ACLYACACBACACAPPARALTB4R | |
| SCHEMBL14269711 | 0.84 | ACLY (0.59) | ACLYACACBACACAPPARALTB4R | |
| Gemcabene SCHEMBL4184554 | 0.84 | ACLY (0.53) | ACLYACACBACACAPPARALTB4R | |
| Gemcabene SCHEMBL528316 | 0.84 | ACLY (0.53) | ACLYACACBACACAPPARALTB4R | |
| SCHEMBL6258161 | 0.84 | ACLY (0.53) | ACLYACACBACACAPPARALTB4R | |
| SCHEMBL5531453 | 0.84 | ACLY (0.59) | ACLYACACBACACAPPARALTB4R | |
| SCHEMBL13515163 | 0.83 | ACLY (0.43) | ACLYACACBACACAPPARALTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030119912-A1 | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith | WARNER-LAMBERT COMPANY | 2003-06-26 | — | — | US | claimed |
| EP-1259474-A1 | CALCIUM DICARBOXYLATE ETHERS, METHODS OF MAKING SAME, AND TREATMENT OF VASCULAR DISEASE AND DIABETES THEREWITH | WARNER-LAMBERT COMPANY (US) | 2002-11-27 | — | — | EP | claimed |
| WO-2001055078-A1 | CALCIUM DICARBOXYLATE ETHERS, METHODS OF MAKING SAME, AND TREATMENT OF VASCULAR DISEASE AND DIABETES THEREWITH | WARNER-LAMBERT COMPANY (GB) | 2001-08-02 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119912-A1 | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith | CACNA1H, CACNA1S, CACNA1C | ACLY 1328/4885ACACB 490/4885ACACA 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.