Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 18/20 | 1.00 |
| ▸ | CTRC | Q99895 | 2/20 | 0.70 |
| ▸ | NSD2 | O96028 | 1/20 | 0.67 |
| ▸ | MMP14 | P50281 | 1/20 | 0.67 |
| ▸ | CASP6 | P55212 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252970 | 1.00 | MPL (1.00) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL10896468 | 0.84 | NSD2 (0.78) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL30371538 | 0.82 | MPL (1.00) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL3010602 | 0.82 | MPL (1.00) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL29362358 | 0.82 | MPL (1.00) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL7247118 | 0.82 | MPL (1.00) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL3346557 | 0.82 | NSD2 (0.76) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL11312764 | 0.82 | MPL (0.69) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL29395671 | 0.82 | MPL (1.00) | MPLCTRCNSD2MMP14CASP6 | |
| SCHEMBL29396122 | 0.82 | MPL (1.00) | MPLCTRCNSD2MMP14CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670387-B1 | Thrombocytopenia; hydroxy-1-azo-naphthalene derivatives; 3-hydroxy-4-((2-hydroxy-1-naphthalenyl)azo-)-1-naphthalenesul fonic acid; promoters of thrombopoiesis and megakaryocytopoi esis; enhancing platelet production; agonizing TPO receptor | SMITHKLINE BEECHAM CORPORATION | 2003-12-30 | — | — | US | claimed |
| EP-1156804-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | claimed |
| EP-1156804-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-28 | — | — | EP | claimed |
| WO-2000035446-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | claimed |
| US-6670387-B1 | Thrombocytopenia; hydroxy-1-azo-naphthalene derivatives; 3-hydroxy-4-((2-hydroxy-1-naphthalenyl)azo-)-1-naphthalenesul fonic acid; promoters of thrombopoiesis and megakaryocytopoi esis; enhancing platelet production; agonizing TPO receptor | SMITHKLINE BEECHAM CORPORATION | 2003-12-30 | — | — | US | disclosed |
| EP-1156804-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1156804-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000035446-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |