Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.38 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 2/20 | 0.38 |
| ▸ | GRK5 | P34947 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724878 | 0.87 | LRRK2 (0.47) | BRAFAURKAAURKBINCENPTPX2 | |
| SCHEMBL10268949 | 0.83 | AURKB (0.46) | AURKAAURKBINCENPTPX2TGFBR1 | |
| SCHEMBL721989 | 0.82 | ACVR1 (0.44) | AURKAAURKBINCENPTPX2 | |
| SCHEMBL724531 | 0.82 | LRRK2 (0.56) | BRAFAURKAAURKBINCENPTPX2 | |
| SCHEMBL10268110 | 0.81 | MET (0.44) | AURKAAURKBINCENPTPX2CCNC | |
| SCHEMBL16817167 | 0.80 | LRRK2 (0.45) | AURKAAURKBINCENPTPX2CCNC | |
| SCHEMBL723582 | 0.80 | CLK2 (0.45) | AURKAAURKBINCENPTPX2TGFBR1 | |
| SCHEMBL725127 | 0.79 | WNT1 (0.42) | BRAFAURKAAURKBINCENPTPX2 | |
| SCHEMBL722397 | 0.78 | AURKB (0.44) | BRAFAURKAAURKBINCENPTPX2 | |
| SCHEMBL724102 | 0.78 | AURKB (0.38) | AURKAAURKBINCENPTPX2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |