Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7254080 | 0.85 | AGTR2 (0.35) | AGTR2 | |
| SCHEMBL919018 | 0.80 | AGTR2 (0.47) | AGTR2 | |
| SCHEMBL6653686 | 0.80 | AGTR2 (0.47) | AGTR2 | |
| SCHEMBL8402776 | 0.80 | AGTR2 (0.47) | AGTR2 | |
| SCHEMBL23458144 | 0.80 | HSD17B10 (0.43) | LMNAMAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL2226550 | 0.80 | KMT2A (0.33) | LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL1833567 | 0.78 | MMP2 (0.41) | ALDH1A1 | |
| SCHEMBL21045619 | 0.77 | POLB (0.35) | AGTR2LMNAMAPTL3MBTL1 | |
| SCHEMBL18952875 | 0.77 | POLB (0.35) | AGTR2LMNAMAPTL3MBTL1 | |
| SCHEMBL26694944 | 0.77 | POLB (0.35) | AGTR2LMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069692-A1 | N-(3-(5-(PYRIMIDIN-4-YL)THIAZOL-4-YL)PHENYL)SULFONAMIDE COMPOUNDS AND THEIR USES AS BRAF INHIBITORS | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2022-10-12 | — | — | EP | disclosed |
| WO-2021110997-A1 | N-(3-(5-(PYRIMIDIN-4-YL)THIAZOL-4-YL)PHENYL)SULFONAMIDE COMPOUNDS AND THEIR USES AS BRAF INHIBITORS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-06-10 | — | — | WO | disclosed |
| WO-2003062232-A1 | DERIVATIVES OF THIAZOLES USED FOR THE TREATMENT OF NEUROLOGICAL DISEASES | SOCIETE DE CONSEILS DE RECHERCHE ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2003-07-31 | — | — | WO | disclosed |