SCHEMBL7255451

SCHEMBL7255451

CN(C)CC1CCc2cc(NC(=O)Nc3cccc(CNc4ccccc4)c3)ccc2C1

nearest known ligand 0.68

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 16/20 0.68
DGAT1 O75907 1/20 0.51
HIF1A Q16665 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7260612 0.94 MCHR1 (0.68) MCHR1DGAT1HIF1A
SCHEMBL7260602 0.94 MCHR1 (0.74) MCHR1DGAT1HIF1A
SCHEMBL7258533 0.93 MCHR1 (0.72) MCHR1DGAT1HIF1A
SCHEMBL7254609 0.90 MCHR1 (0.71) MCHR1DGAT1
SCHEMBL7258284 0.87 MCHR1 (0.66) MCHR1DGAT1
SCHEMBL7260545 0.86 MCHR1 (0.73) MCHR1DGAT1
SCHEMBL7254656 0.86 MCHR1 (0.76) MCHR1DGAT1
SCHEMBL7260417 0.86 MCHR1 (0.65) MCHR1DGAT1
SCHEMBL7254898 0.86 MCHR1 (0.73) MCHR1DGAT1
SCHEMBL7255504 0.86 MCHR1 (0.79) MCHR1DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003087046-A1 NOVEL AMINOTETRALINE COMPOUNDS FOR USE IN MCH RECEPTOR RELATED DISORDERS 7TM PHARMA A/S (DK) 2003-10-23 WO disclosed