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SCHEMBL7260612

SCHEMBL7260612

CN(C)CC1CCc2cc(NC(=O)Nc3cccc(NCc4ccccc4)c3)ccc2C1

nearest known ligand 0.68

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MCHR1 Q99705 16/20 0.68
▸ DGAT1 O75907 1/20 0.51
▸ HSD17B3 P37058 1/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ NPC1 O15118 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ HIF1A Q16665 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7255451 0.94 MCHR1 (0.68) MCHR1DGAT1HIF1A
SCHEMBL7260602 0.94 MCHR1 (0.74) MCHR1DGAT1MEN1NPC1RAB9A
SCHEMBL7258533 0.93 MCHR1 (0.72) MCHR1DGAT1MEN1NPC1RAB9A
SCHEMBL7254609 0.88 MCHR1 (0.71) MCHR1DGAT1MEN1NPC1RAB9A
SCHEMBL7260545 0.88 MCHR1 (0.73) MCHR1DGAT1MEN1NPC1RAB9A
SCHEMBL7254656 0.86 MCHR1 (0.76) MCHR1DGAT1MEN1NPC1RAB9A
SCHEMBL7255504 0.86 MCHR1 (0.79) MCHR1DGAT1MEN1NPC1RAB9A
SCHEMBL7258284 0.85 MCHR1 (0.66) MCHR1DGAT1MEN1NPC1RAB9A
SCHEMBL7255931 0.85 MCHR1 (0.66) MCHR1DGAT1MEN1NPC1RAB9A
SCHEMBL7260349 0.84 MCHR1 (0.71) MCHR1DGAT1MEN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003087046-A1 NOVEL AMINOTETRALINE COMPOUNDS FOR USE IN MCH RECEPTOR RELATED DISORDERS 7TM PHARMA A/S (DK) 2003-10-23 — — WO disclosed