Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.42 |
| ▸ | DRD3 | P35462 | 14/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255815 | 0.88 | DRD2 (0.49) | DRD2DRD3 | |
| SCHEMBL4393692 | 0.87 | DRD2 (0.52) | DRD2DRD3HRH4 | |
| SCHEMBL7251876 | 0.86 | DRD3 (0.56) | DRD2DRD3 | |
| SCHEMBL4394940 | 0.85 | DRD2 (0.49) | DRD2DRD3HRH4 | |
| SCHEMBL7257699 | 0.83 | DRD2 (0.41) | DRD2DRD3HRH3 | |
| SCHEMBL7252084 | 0.83 | DRD3 (0.57) | DRD2DRD3 | |
| SCHEMBL6600963 | 0.83 | DRD2 (0.53) | DRD2DRD3 | |
| SCHEMBL388042 | 0.76 | DRD2 (0.45) | DRD2DRD3 | |
| SCHEMBL4392664 | 0.73 | DRD2 (0.40) | DRD2DRD3HRH4 | |
| SCHEMBL4392669 | 0.73 | DRD2 (0.40) | DRD2DRD3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003002543-A1 | PYRIMIDINOXYALKYLPIPERAZINES AND THEIR THERAPEUTIC USE | ABBOTT LABORATORIES (US) | 2003-01-09 | — | — | WO | disclosed |