Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 8/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 8/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258507 | 0.89 | HRH4 (0.55) | HRH4HRH1HTR3ANPC1CTNNB1 | |
| SCHEMBL7260290 | 0.84 | HRH4 (0.54) | HRH4HRH1HTR3ANPC1CLK4 | |
| SCHEMBL7259297 | 0.83 | HRH1 (0.50) | HRH4HRH1CTNNB1TCF7L2 | |
| SCHEMBL7254578 | 0.83 | HRH4 (0.60) | HRH4HRH1HTR3ANPC1CLK4 | |
| SCHEMBL7258098 | 0.81 | HRH1 (0.47) | HRH4HRH1NPC1CTNNB1TCF7L2 | |
| SCHEMBL7254519 | 0.80 | NPC1 (0.52) | HRH4HRH1NPC1CTNNB1TCF7L2 | |
| SCHEMBL7259508 | 0.78 | HRH4 (0.52) | HRH4HRH1HTR3ANPC1CLK4 | |
| SCHEMBL2590769 | 0.75 | RAD52 (0.68) | HRH4HTR3A | |
| SCHEMBL7254511 | 0.75 | LMNA (0.56) | CTNNB1TCF7L2CLK4 | |
| SCHEMBL21686898 | 0.71 | HRH4 (1.00) | HRH4HRH1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003055866-A1 | QUINAZOLINE AND QUINOLINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-10 | — | — | WO | disclosed |