Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.64 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.62 |
| ▸ | TCF7L2 | Q9NQB0 | 7/20 | 0.62 |
| ▸ | HTR3A | P46098 | 4/20 | 0.61 |
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | PDE1A | P54750 | 1/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255329 | 0.91 | HRH4 (0.61) | HRH4CTNNB1TCF7L2HTR3APDE4A | |
| SCHEMBL7258127 | 0.88 | HRH4 (0.60) | HRH4CTNNB1TCF7L2HTR3APDE4A | |
| SCHEMBL3642575 | 0.86 | CTNNB1 (0.68) | HRH4CTNNB1TCF7L2PDE4APDE4B | |
| SCHEMBL7259546 | 0.86 | KMT5A (0.59) | CTNNB1TCF7L2 | |
| SCHEMBL3642119 | 0.84 | HRH4 (0.80) | HRH4CTNNB1TCF7L2HTR3APDE4A | |
| SCHEMBL7254637 | 0.83 | CNR1 (0.58) | HRH4CTNNB1TCF7L2HTR3APDE5A | |
| SCHEMBL3643109 | 0.80 | CTNNB1 (0.60) | HRH4CTNNB1TCF7L2PDE4APDE4B | |
| SCHEMBL7260501 | 0.79 | CTNNB1 (0.65) | CTNNB1TCF7L2 | |
| SCHEMBL7259303 | 0.78 | KMT5A (0.55) | CTNNB1TCF7L2 | |
| SCHEMBL3605981 | 0.78 | HRH4 (1.00) | HRH4HTR3AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003055866-A1 | QUINAZOLINE AND QUINOLINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-10 | — | — | WO | disclosed |