Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16052176 | 0.78 | MAPT (0.47) | NPC1RAB9ALMNAMAPTKMT2A | |
| SCHEMBL3174451 | 0.77 | ADORA3 (0.48) | LMNAKMT2APOLBADORA3ADORA2A | |
| SCHEMBL3716787 | 0.75 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LMNANR1H2 | |
| SCHEMBL23853930 | 0.74 | GAA (0.53) | GSK3AGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30675639 | 0.72 | AURKB (0.51) | GSK3AGSK3BRAB9AJAK2MAP4K4 | |
| SCHEMBL13329926 | 0.72 | AURKB (0.51) | GSK3AGSK3BRAB9AJAK2MAP4K4 | |
| SCHEMBL4697304 | 0.72 | RET (0.41) | GSK3AGSK3BKDRAURKBADORA2A | |
| SCHEMBL30822335 | 0.72 | RET (0.41) | GSK3AGSK3BKDRAURKBADORA2A | |
| SCHEMBL3762000 | 0.72 | HPGDS (0.47) | HPGDSGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5387619 | 0.71 | GSK3B (0.59) | GSK3AGSK3BJAK2MAP4K4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |
| WO-2003080617-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |