Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 6/20 | 0.50 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752936 | 0.83 | CASP1 (0.46) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL7436005 | 0.83 | CASP1 (0.46) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL1752896 | 0.81 | CASP1 (0.44) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL581419 | 0.79 | CASP1 (0.53) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL1752842 | 0.78 | CASP1 (0.47) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL1752831 | 0.76 | SMARCA2 (0.59) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL1752940 | 0.75 | CASP1 (0.45) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL1752930 | 0.74 | MEN1 (0.44) | CASP1SMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL1752910 | 0.73 | CASP1 (0.43) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL530338 | 0.73 | CASP1 (0.57) | CASP1SMARCA2SMARCA4PBRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |