Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CD38 | P28907 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6083926 | 1.00 | NPC1 (0.56) | NPC1RAB9AKMT2AHPGDSKDM4E | |
| SCHEMBL6084961 | 0.83 | NPC1 (0.62) | NPC1RAB9AKMT2AHPGDSLMNA | |
| SCHEMBL7508967 | 0.83 | NPC1 (0.62) | NPC1RAB9AKMT2AHPGDSLMNA | |
| SCHEMBL6083629 | 0.79 | RAB9A (0.53) | NPC1RAB9AHPGDSHPGDALDH1A1 | |
| SCHEMBL6085524 | 0.79 | RAB9A (0.53) | NPC1RAB9AHPGDSHPGDALDH1A1 | |
| SCHEMBL6083620 | 0.79 | RAB9A (0.53) | NPC1RAB9AHPGDSHPGDALDH1A1 | |
| SCHEMBL6085336 | 0.79 | HPGDS (0.55) | NPC1RAB9AKMT2AHPGDSLMNA | |
| SCHEMBL6085327 | 0.79 | HPGDS (0.55) | NPC1RAB9AKMT2AHPGDSLMNA | |
| SCHEMBL6085438 | 0.77 | RAB9A (0.52) | NPC1RAB9AKMT2AKDM4EMAPK1 | |
| SCHEMBL6085244 | 0.77 | HPGDS (0.77) | HPGDSCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500480-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1196397-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMACEUTICALS, INC. (US) | 2002-04-17 | — | — | EP | claimed |
| WO-2000073283-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMACEUTICALS, INC. (US) | 2000-12-07 | — | — | WO | claimed |