Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7256324 | 0.96 | TNF (0.46) | TNFLMNAPARP1NPC1RAB9A | |
| SCHEMBL7256534 | 0.91 | PARP1 (0.50) | TNFLMNAPARP1NPC1RAB9A | |
| SCHEMBL4591134 | 0.81 | ALDH1A1 (0.47) | LMNAHDAC6TP53POLBSMN1; SMN2 | |
| SCHEMBL216346 | 0.81 | CNR2 (0.46) | TNFNPC1RAB9ACNR2DRD2 | |
| SCHEMBL14221996 | 0.80 | PARP1 (0.44) | TNFPARP1TP53CNR2KAT2A | |
| SCHEMBL1129892 | 0.79 | DRD2 (0.44) | TNFLMNANPC1RAB9AHDAC6 | |
| SCHEMBL7256476 | 0.78 | EGLN1 (0.47) | TNFPARP1KAT2AKAT2B | |
| SCHEMBL7261808 | 0.78 | DRD2 (0.40) | TNFNPC1RAB9AHDAC6RXFP1 | |
| SCHEMBL16509712 | 0.78 | NPC1 (0.53) | TNFLMNANPC1RAB9ACNR2 | |
| SCHEMBL6189205 | 0.77 | TNF (0.74) | TNFHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103668-A1 | PYRIDIN-2-ONE AND QUINOLIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS ANTIBACTERIALS | KARO BIO AB (SE) | 2003-12-18 | — | — | WO | disclosed |