SCHEMBL725678

SCHEMBL725678

CN(C)C(=N)NC(N)=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2642702 0.97 CRBN (0.42)
Glycine SCHEMBL2192780 0.87 GLRA1 (0.40)
Succinic Acid SCHEMBL7644469 0.87 PHF8 (0.41)
Metformin SCHEMBL4410446 0.78 CRBN (0.33)
Metformin SCHEMBL4364474 0.78 LMNA (0.30)
Metformin SCHEMBL1323029 0.78 CRBN (0.33)
Metformin SCHEMBL8944 0.78
Metformin SCHEMBL1766280 0.78 LMNA (0.36)
Metformin SCHEMBL28844380 0.77
Metformin SCHEMBL3688836 0.77 HTT (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 411 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240029844-A1 METHODS FOR LOWERING BLOOD SUGAR WITH A METFORMIN PHARMACEUTICAL COMPOSITION ASTRAZENECA UK LIMITED (GB) 2024-01-25 US claimed
US-20230364037-A1 CANCER THERAPEUTIC GILLIES MCINDOE RESEARCH INSTITUTE (NZ) 2023-11-16 US claimed
EP-4218819-A2 COMBINATION THERAPY BASED ON PD-1 SIGNAL INHIBITORS Kyoto University (JP) 2023-08-02 EP claimed
US-11547699-B2 [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate for use in lymphangioleiomyomatosis and other diseases KOESTER HUBERT (DE) 2023-01-10 US claimed
US-20210369682-A1 [2-[(5-NITRO-1,3-THIAZOL-2-YL)CARBAMOYL]PHENYL]ETHANOATE FOR USE IN LYMPHANGIOLEIOMYOMATOSIS AND OTHER DISEASES KOESTER HUBERT (DE) 2021-12-02 US claimed
EP-3807895-A1 METHODS FOR LOWERING BLOOD SUGAR WITH A METFORMIN PHARMACEUTICAL COMPOSITION AstraZeneca UK Limited (GB) 2021-04-21 EP claimed
US-20200197335-A1 CANCER THERAPEUTIC GILLIES MCINDOE RESEARCH INSTITUTE (NZ) 2020-06-25 US claimed
US-20180362650-A1 PD-1 SIGNAL INHIBITOR COMBINATION THERAPY KYOTO UNIVERSITY (JP) 2018-12-20 US claimed
EP-3388084-A1 PD-1 SIGNAL INHIBITOR COMBINATION THERAPY Kyoto University (JP) 2018-10-17 EP claimed
WO-2018143826-A1 CANCER THERAPEUTIC GILLIES MCINDOE RESEARCH INSTITUTE (NZ) 2018-08-09 WO claimed
US-20050136017-A1 Cosmetic containing an imine reactive with the cystines of keratin fibers via a beta-elimination reaction to produce dehydroalanine and lead to formation of lanthionine in a medium free of polyhydroxylated alkane; guanidine and/or amidine imines such as dimethylguanidine; noncaustic for use on hair, skin L'OREAL S.A. (FR) 2005-06-23 US claimed
US-20050129645-A1 Hair shaping composition comprising at least one non-hydroxide imine L'OREAL 2005-06-16 US claimed
EP-1532963-A1 Composition for straightening the hair comprising at least one imine not being an hydroxide L'OREAL (FR) 2005-05-25 EP claimed
EP-1532960-A1 Hair styling composition containing a non-hydroxide imine L'OREAL (FR) 2005-05-25 EP claimed
WO-2005033089-A1 SALT OF 6-(1, 3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-4-HEXENOIC ACID WITH N, N-DIMETHYL-IMIDODICARBONIMIDIC DIAMIDE BIOCON LIMITED (IN) 2005-04-14 WO claimed
WO-2005033067-A1 SALT OF 1,2,6,7,8,8A-HEXAHYDRO-β,δ,6-TRIHYDROXY-2-METHYL-8-[(2S)-2-METHYL-1-OXOBUTOXY]-, (βR,δ R,1S,2S,6S,8S,8AR)- 1-NAPHTHALENEHEPTANOIC ACID WITH N,N-DIMETHYL-IMIDODICARBONIMIDIC DIAMIDE BIOCON LIMITED (IN) 2005-04-14 WO claimed
US-20030219440-A1 3-deoxyglucosone and skin DYNAMIS THERAPEUTICS, INC. 2003-11-27 US claimed
WO-2002012177-A1 COMPOSITION OF METFORMIN WITH SUCCINIC ACID OR SALTS THEREOF AND METHOD FOR TREATING DIABETES POMYTKIN IGOR ANATOLIEVICH (RU) 2002-02-14 WO claimed
WO-1992007560-A1 BIGUANIDES AND DERIVATIVES THEREOF AS INHIBITORS OF ADVANCED GLYCOSYLATION OF A TARGET PROTEIN THE ROCKEFELLER UNIVERSITY (US) 1992-05-14 WO claimed
US-5100919-A Aging resistance; food preservatives THE ROCKEFELLER UNIVERSITY (US) 1992-03-31 US claimed