Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 8/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 8/20 | 0.41 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.36 |
| ▸ | KDM5C | P41229 | 5/20 | 0.36 |
| ▸ | KDM6B | O15054 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL2192780 | 0.88 | GLRA1 (0.40) | CRBN | |
| Metformin SCHEMBL7647374 | 0.88 | PHF8 (0.41) | PHF8KDM2AKDM7AEGLN1KDM5C | |
| Metformin SCHEMBL1558869 | 0.88 | PHF8 (0.41) | PHF8KDM2AKDM7AEGLN1KDM5C | |
| SCHEMBL725678 | 0.87 | — | — | |
| Metformin SCHEMBL7123890 | 0.86 | PHF8 (0.39) | PHF8KDM2AKDM7AEGLN1KDM5C | |
| Hydrochloric Acid SCHEMBL2642702 | 0.85 | CRBN (0.42) | LMNACRBN | |
| Adipic Acid SCHEMBL2812145 | 0.81 | LMNA (0.41) | LMNA | |
| Metformin SCHEMBL2815209 | 0.81 | SLC22A6 (0.41) | PHF8KDM2AKDM7ALMNAGABRR1 | |
| Metformin SCHEMBL991940 | 0.79 | FFAR3 (0.46) | PHF8KDM2AKDM7AFFAR3HDAC3 | |
| Metformin SCHEMBL2231852 | 0.78 | LDHA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002012177-A1 | COMPOSITION OF METFORMIN WITH SUCCINIC ACID OR SALTS THEREOF AND METHOD FOR TREATING DIABETES | POMYTKIN IGOR ANATOLIEVICH (RU) | 2002-02-14 | — | — | WO | claimed |
| WO-2002012177-A1 | COMPOSITION OF METFORMIN WITH SUCCINIC ACID OR SALTS THEREOF AND METHOD FOR TREATING DIABETES | POMYTKIN IGOR ANATOLIEVICH (RU) | 2002-02-14 | — | — | WO | disclosed |