Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263030 | 0.97 | SIGMAR1 (0.49) | SIGMAR1OPRM1KCNH2DRD4SLC6A4 | |
| SCHEMBL7262985 | 0.94 | SIGMAR1 (0.55) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL7262982 | 0.88 | SIGMAR1 (0.45) | SIGMAR1OPRM1KCNH2DRD4 | |
| SCHEMBL7258399 | 0.85 | HRH3 (0.45) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL7258219 | 0.82 | SIGMAR1 (0.43) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL7257271 | 0.82 | SIGMAR1 (0.44) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL7262094 | 0.82 | SIGMAR1 (0.42) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL7262783 | 0.81 | SIGMAR1 (0.50) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL7261688 | 0.81 | SIGMAR1 (0.41) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL7263043 | 0.81 | ITGB3 (0.39) | SIGMAR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346994-A1 | CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | claimed |
| EP-1346994-A1 | CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | disclosed |