Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 9/20 | 0.69 |
| ▸ | DHFR | P00374 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638076 | 0.90 | TYMS (0.81) | TYMSDHFR | |
| SCHEMBL7501783 | 0.90 | TYMS (0.78) | TYMSDHFR | |
| SCHEMBL7990232 | 0.90 | TYMS (0.78) | TYMSDHFR | |
| Osi-7904 SCHEMBL2195534 | 0.82 | TYMS (1.00) | TYMSDHFR | |
| Osi-7904 SCHEMBL29389995 | 0.82 | TYMS (1.00) | TYMSDHFR | |
| Osi-7904 SCHEMBL29692323 | 0.82 | TYMS (1.00) | TYMSDHFR | |
| Osi-7904 SCHEMBL29692303 | 0.82 | TYMS (1.00) | TYMSDHFR | |
| Osi-7904 SCHEMBL7207397 | 0.82 | TYMS (1.00) | TYMSDHFR | |
| SCHEMBL6450938 | 0.81 | TYMS (0.65) | TYMSDHFR | |
| SCHEMBL7257431 | 0.76 | THRB (0.46) | THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728018-B1 | New enzymes and prodrugs for ADEPT | WELLCOME FOUND (GB) | 2003-08-06 | — | — | EP | disclosed |
| US-6319702-B1 | NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER | GLAXO WELLCOME, INC. | 2001-11-20 | — | — | US | disclosed |
| US-6140100-A | CONJUGATE POLYPEPTIDE WHICH IS TISSUE PREFERENTIAL; ANTICARCINOGENIC AGENTS | GLAXO WELLCOME INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0728018-A1 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013095-A2 | THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |