Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 9/20 | 0.78 |
| ▸ | DHFR | P00374 | 4/20 | 0.42 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501783 | 1.00 | TYMS (0.78) | TYMSDHFRSLC19A1 | |
| SCHEMBL6450938 | 0.91 | TYMS (0.65) | TYMSDHFRSLC19A1 | |
| SCHEMBL7258331 | 0.90 | TYMS (0.69) | TYMSDHFR | |
| Osi-7904 SCHEMBL2195534 | 0.88 | TYMS (1.00) | TYMSDHFRSLC19A1 | |
| Osi-7904 SCHEMBL7207397 | 0.88 | TYMS (1.00) | TYMSDHFRSLC19A1 | |
| Osi-7904 SCHEMBL29389995 | 0.88 | TYMS (1.00) | TYMSDHFRSLC19A1 | |
| Osi-7904 SCHEMBL29692303 | 0.88 | TYMS (1.00) | TYMSDHFRSLC19A1 | |
| Osi-7904 SCHEMBL29692323 | 0.88 | TYMS (1.00) | TYMSDHFRSLC19A1 | |
| SCHEMBL7987650 | 0.81 | TYMS (0.78) | TYMSDHFR | |
| SCHEMBL2638076 | 0.80 | TYMS (0.81) | TYMSDHFRSLC19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306865-B1 | SYNTHASE INHIBITORS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-10-23 | — | — | US | disclosed |